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Literature summary extracted from

  • Shen, R.S.; Smith, R.V.; Davis, P.J.; Abell, C.W.
    Inhibition of dihydropteridine reductase from human liver and rat striatal synaptosomes by apomorphine and its analogs (1984), J. Biol. Chem., 259, 8994-9000.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.34 (R)-2,10,11-trihydroxy-N-n-propylaporphine 0.0017 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-2,10,11-trihydroxy-N-n-propylaporphine 0.0016 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-2,10,11-trihydroxyaporphine 0.0016 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-2,10,11-trihydroxyaporphine 0.0007 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-2,11-dihydroxy-10-methoxy-aporphine 0.013 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-2,11-dihydroxy-10-methoxy-aporphine 0.016 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-apocodeine 0.079 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-apocodeine 0.087 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-apomorphine 0.002 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-apomorphine 0.0012 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-N-chloroethylnorapomorphine 0.0029 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-N-chloroethylnorapomorphine 0.0029 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-N-hydroxyethylnorapomorphine 0.001 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-N-hydroxyethylnorapomorphine 0.0013 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-N-n-propylaporphine
-
 Homo sapiens
1.5.1.34 (R)-N-n-propylaporphine
-
 Rattus norvegicus
1.5.1.34 (R)-N-n-propylnorapomorphine 0.0018 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-N-n-propylnorapomorphine 0.0017 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (R)-norapomorphine 0.0028 mM, 50% inhibition Homo sapiens
1.5.1.34 (R)-norapomorphine 0.0014 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (S)-2,10,11-trihydroxyaporphine 0.0015 mM, 50% inhibition Homo sapiens
1.5.1.34 (S)-2,10,11-trihydroxyaporphine 0.0014 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (S)-bulbocapnine 0.148 mM, 50% inhibition Homo sapiens
1.5.1.34 (S)-bulbocapnine 0.151 mM, 50% inhibition Rattus norvegicus
1.5.1.34 (S)-N-n-propylnorapomorphine 0.0022 mM, 50% inhibition Homo sapiens
1.5.1.34 (S)-N-n-propylnorapomorphine 0.0018 mM, 50% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.34 synaptosome striatum Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-
1.5.1.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 liver
-
 Homo sapiens
-
1.5.1.34 liver
-
 Rattus norvegicus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.34 0.0012
-
 (R)-apomorphine
-
 Rattus norvegicus
1.5.1.34 0.0013
-
 (R)-N-n-propylaporphine
-
 Rattus norvegicus
1.5.1.34 0.0019
-
 (R)-2,10,11-trihydroxyapomorphine
-
 Homo sapiens
1.5.1.34 0.0019
-
 (R)-2,10,11-trihydroxyapomorphine
-
 Rattus norvegicus
1.5.1.34 0.0022
-
 (R)-apomorphine
-
 Homo sapiens
1.5.1.34 0.0022
-
 (R)-N-n-propylaporphine
-
 Homo sapiens